Ketamine Therapy in St. Louis:
At a Glance

• Treatment: Ketamine-assisted psychotherapy (KAP)

• Format: Virtual treatment with an at-home component for eligible adults

• Service area: St. Louis and throughout Missouri

• Approach: Psychiatric evaluation, preparation, ketamine-assisted sessions, and integration

• Clinician: Ryan Sheridan, DNP, PMHNP-BC

• Payment: Private-pay, with superbills for eligible services

• Treatment plans: Individualized rather than mandatory multi-session packages

Ketamine treatment is offered only after an individualized evaluation determines that it is clinically appropriate and legally permissible.

What Is Ketamine-Assisted Psychotherapy?

Ketamine-assisted psychotherapy combines prescribed ketamine with a structured therapeutic process.

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Ketamine can temporarily alter perception, attention, emotional experience, and patterns of thought. In a psychotherapy-oriented setting, these effects may create opportunities for reflection and exploration.

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However, ketamine does not reliably produce particular insights or guarantee lasting symptom improvement.

At Proactive Psychiatry, the medication is only one component of care. Preparation, therapeutic support, integration, and continued psychiatric assessment are equally important parts of the treatment model.

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Rather than approaching ketamine as an isolated intervention, we consider how it fits within your overall mental health treatment.

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A Different Approach to Ketamine Treatment in St. Louis

St. Louis patients have access to multiple treatment models, including IV infusions, clinic-based esketamine, and ketamine-assisted psychotherapy.

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Proactive Psychiatry takes a psychotherapy-oriented approach.

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One Consistent Clinician

Your psychiatric evaluation, treatment planning, prescribing decisions, ketamine-assisted sessions, and integration are coordinated by Ryan Sheridan, DNP, PMHNP-BC.

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Working with one clinician allows information from each stage of care to inform the next, without repeatedly explaining your history to new providers.

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Comprehensive Psychiatric Care

Ketamine is considered within your broader mental health picture.

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This may include your psychiatric history, current medications, psychotherapy, sleep, physical health, lifestyle, and previous treatment response.

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The goal is to determine whether ketamine is appropriate, not to assume everyone seeking treatment needs it.

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Treatment With Preparation and Integration

Ketamine-assisted psychotherapy includes intentional preparation before treatment and opportunities to process the experience afterward.

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Integration sessions help connect therapeutic experiences with practical changes in daily life.

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Individualized Rather Than Subscription-Based

You will not be required to purchase a predetermined package of ketamine sessions.

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The number and timing of appointments depend on your clinical needs, treatment response, tolerability, and goals.

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How Virtual Ketamine-Assisted Therapy Works

Step 1: Comprehensive Psychiatric Evaluation

75 minutes | $799

Your treatment begins with a comprehensive psychiatric evaluation to review symptoms, psychiatric and medical history, previous treatment, current medications, treatment goals, and potential risks.

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This evaluation helps determine whether ketamine-assisted therapy should be considered or whether another treatment approach may be more appropriate.

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An evaluation does not guarantee eligibility for ketamine treatment.

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Step 2: Preparation, if needed

50 minutes | $399 

Preparation focuses on establishing treatment goals, discussing possible psychological and physical effects, reviewing safety requirements, and developing a plan for the experience.

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You will have an opportunity to ask questions and understand what is expected before proceeding.

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Step 3: Ketamine-Assisted Psychotherapy

110 minutes | $649

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For appropriately selected patients, an at-home treatment session may take place in a suitable private environment with real-time virtual clinical support.

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Sessions are individualized and may incorporate supportive psychotherapy, reflection, and therapeutic processing.

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Clinical screening, monitoring plans, emergency procedures, support-person requirements, and post-treatment restrictions are established before treatment.

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Step 4: Integration and Follow-Up

50 minutes | $399

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Integration focuses on reflecting on the experience and considering how it relates to symptoms, relationships, coping patterns, behavior, and treatment goals.

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Ongoing care may include additional psychotherapy, medication management, behavioral strategies, or other psychiatric treatment as clinically indicated.

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What Mental Health Conditions May Be Considered?

Ketamine is studied and used off-label in selected psychiatric treatment settings, particularly for depression.

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Adults exploring ketamine-assisted psychotherapy may be experiencing:

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• Depression, including symptoms that have persisted despite previous treatment

• Anxiety and difficulties with emotional regulation

• Trauma-related symptoms

• Psychological patterns that have remained challenging despite conventional treatment

The evidence differs substantially across these conditions. Interest in ketamine does not establish that it is an appropriate or effective treatment for a particular diagnosis.

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Your evaluation considers both potential benefits and risks, including whether a more established treatment should be recommended.

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At-Home Ketamine Therapy vs. IV Ketamine Infusions

There are important differences between virtual ketamine-assisted psychotherapy and IV ketamine treatment.

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At-home ketamine-assisted psychotherapy uses a prescribed medication protocol and places particular emphasis on the therapeutic relationship, preparation, supported sessions, and integration.

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IV ketamine treatment involves medication administered intravenously in a clinical facility, with in-person medical monitoring and a different dosing and treatment structure.

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Spravato (esketamine) is another distinct treatment, with FDA-approved indications and required administration in a certified healthcare setting.

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These treatments should not be considered interchangeable, and at-home KAP is not appropriate for everyone.

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Proactive Psychiatry's St. Louis offering focuses on virtual ketamine-assisted psychotherapy, not IV infusion services.

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Ketamine Therapy Pricing

in St. Louis

Proactive Psychiatry provides transparent, private-pay pricing without requiring patients to purchase a large treatment package.

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Current professional fees:

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• Comprehensive Psychiatric Evaluation: $799 | 75 minutes

• Ketamine Preparation or Integration: $399 | 50 minutes

• Standard KAP Session: $649 | 110 minutes

• Ketamine Prescription: Up to $50 per session, when applicable

Medication costs charged by a dispensing pharmacy are separate.

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The total cost depends on the number and types of appointments recommended.

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Proactive Psychiatry is an out-of-network practice. Superbills can be provided for eligible services, although reimbursement is not guaranteed.

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View Full Ketamine Therapy Pricing

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Is At-Home

Ketamine Therapy Safe?

Ketamine can cause dissociation, sedation, impaired coordination, changes in blood pressure and heart rate, nausea, and other physical or psychological effects.

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At-home treatment introduces additional considerations because a healthcare professional is not physically present.

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Careful patient selection, medication review, appropriate monitoring arrangements, safety planning, and follow-up are essential.

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Some individuals may be better served by treatment in a medically supervised facility, and others may not be appropriate candidates for ketamine.

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Ketamine Therapy Throughout

St. Louis and Missouri

Proactive Psychiatry serves eligible adults located in Missouri, including the St. Louis metropolitan area.

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This includes communities such as St. Louis City, St. Louis County, Kirkwood, Webster Groves, Clayton, Ladue, Creve Coeur, Chesterfield, and St. Charles.

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Virtual ketamine-assisted treatment is subject to the patient's physical location, applicable prescribing laws, clinical eligibility, and treatment-specific safety requirements.

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Frequently Asked Questions

Can I receive ketamine therapy at home in St. Louis?

At-home ketamine-assisted psychotherapy may be available for eligible adults physically located in Missouri. A comprehensive evaluation is required to determine whether this treatment setting is appropriate.

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Is ketamine therapy FDA-approved for depression?

Ketamine itself is not FDA-approved for psychiatric disorders. Its psychiatric use is off-label. Esketamine (Spravato) is a separate medication with specific FDA-approved psychiatric indications.

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Will I see the same clinician throughout treatment?

Yes. Proactive Psychiatry's model is designed around continuity with Ryan Sheridan, DNP, PMHNP-BC, from evaluation and preparation through ketamine care and integration.

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Do I need a referral?

No referral is required to request an initial consultation. Whether treatment is appropriate is determined during the clinical evaluation.

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How many ketamine sessions will I need?

There is no universal number. Treatment plans are individualized based on clinical needs, response, potential risks, and ongoing assessment.

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Explore Ketamine Therapy

in St. Louis

If you are considering ketamine-assisted psychotherapy, the first step is understanding whether the treatment is appropriate for your mental health needs and goals.

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Proactive Psychiatry offers a personalized approach built around comprehensive psychiatric care, consistent clinician involvement, and thoughtful integration.

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Request a free 15-minute introductory consultation to learn more about the treatment process.

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Request a Free Intro

Clinical content: Ryan Sheridan, DNP, PMHNP-BC — Board-Certified Psychiatric-Mental Health Nurse Practitioner.

Important information: Ketamine is FDA-approved as an anesthetic but is not FDA-approved to treat psychiatric disorders. Compounded ketamine medications are not FDA-approved, and at-home use carries additional safety risks. Treatment is subject to medical evaluation and applicable legal and prescribing requirements. This page is educational and does not provide individualized medical advice.